SILC1

Across TCGA patient cohorts, SILC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,211 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SILC1-associated proteins across cancer lineages are ADD1, TMOD2, and MCF2L. Each is linked with SILC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SILC1-to-partner and partner-to-SILC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SILC1 versus ADD1 in GBM, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SILC1→partner) and Y-score (partner→SILC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADD1 →	+0.450	+1.661	<.001	<.001	3	4
GBM	TMOD2 →	+0.528	+1.386	<.001	<.001	3	3
GBM	MCF2L →	+0.314	+1.029	<.001	<.001	3	3
OV	MRPL1 →	-0.379	-0.129	.001	.001	2	4
LSCC	MRPL37 →	-0.351	-0.038	<.001	<.001	2	4
GBM	MRPS34 →	-0.382	-1.136	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,211 associations by consensus.

SILC1 vs ADD1 — GBM

Explore this scatter interactively →