SILC1

Across TCGA patient cohorts, SILC1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SILC1-associated genes across cancer lineages are STAT3_pY705, Caspase-8, and EGFR_pY1068. Each is linked with SILC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SILC1-to-partner and partner-to-SILC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by SILC1-low versus SILC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SILC1→partner) and Y-score (partner→SILC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.518	-3.000	<.001	.037	3	1
UCEC	Caspase-8 →	-0.316	-3.000	.029	.036	2	1
UCEC	EGFR_pY1068 →	-0.315	-3.000	.030	.037	1	1
UCEC	A-Raf_pS299 →	-0.188	-3.000	.006	.037	1	1
UCEC	JNK2 →	+0.321	+3.000	.005	.037	1	1
UCEC	p38-MAPK_pT180_Y182 →	-0.577	-2.986	.026	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

STAT3_pY705 by SILC1 expression — UCEC

Explore this box plot interactively →