SIL1

Across TCGA pan-cancer cohorts, SIL1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SIL1 data layer compared with 20 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SIL1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SIL1 expression acts as an unfavorable survival marker.

COAD, UCS, and KICH are the cancer types where SIL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.001	0.871	<.001	24	view →
UCS	OS	Median	All	0.226	0.695	.004	18	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SIL1–COAD (OS)

Open the COAD breakdown →