SIL1

Across TCGA patient cohorts, SIL1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,578 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SIL1-associated genes across cancer lineages are HSPA5, GAB1, and TMED9. Each is linked with SIL1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SIL1-to-partner and partner-to-SIL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIL1 versus HSPA5 in GBM, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIL1→partner) and Y-score (partner→SIL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HSPA5 →	+0.597	+0.390	<.001	<.001	3	6
GBM	GAB1 →	-0.701	-0.327	<.001	<.001	3	5
BRCA	TMED9 →	+0.481	+0.425	<.001	<.001	3	5
BRCA	LMAN2 →	+0.536	+0.386	<.001	<.001	3	5
BRCA	SRSF5 →	-0.561	-0.297	.001	<.001	3	4
GBM	ZNF175 →	-0.476	-0.317	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,578 associations by consensus.

SIL1 vs HSPA5 — GBM

Explore this scatter interactively →