SIL1

Across TCGA patient cohorts, SIL1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIL1-associated genes across cancer lineages are Cyclin-B1, PCNA, and Caspase-7-cleavedD198. Each is linked with SIL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIL1-to-partner and partner-to-SIL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SIL1-low versus SIL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIL1→partner) and Y-score (partner→SIL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.667	+3.459	.018	.005	3	2
UCEC	PCNA →	+0.218	+3.459	.044	.005	3	1
UCEC	Caspase-7-cleavedD198 →	+1.082	+3.479	<.001	.002	3	1
UCEC	Caspase-8 →	-0.254	-3.295	.044	.009	3	1
UCEC	MEK1 →	+0.588	+3.459	.001	.005	1	2
UCEC	4E-BP1_pS65 →	-0.223	-2.308	.023	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Cyclin-B1 by SIL1 expression — UCEC

Explore this box plot interactively →