SIL1

Across TCGA cell cohorts, SIL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,960 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SIL1-associated GO terms across cancer lineages are Cotranslational protein targeting to membrane, Glycoprotein catabolic process, and Positive regulation of protein exit from endoplasmic reticulum. Each is linked with SIL1 in more than 16 cancer types. Because this analysis shows association rather than direction, both SIL1-to-partner and partner-to-SIL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cotranslational protein targeting to membrane grouped by SIL1-low versus SIL1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIL1→partner) and Y-score (partner→SIL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cotranslational protein targeting to membrane →	+0.130	+0.922	<.001	<.001	3	17
BONE	Glycoprotein catabolic process →	+0.165	+0.775	<.001	<.001	3	16
BLOOD_Myeloma	Positive regulation of protein exit from endoplasmic reticulum →	+0.136	+1.436	<.001	<.001	3	15
LUNG_SCLC	Mannose metabolic process →	+0.141	+1.033	.001	.009	3	14
BONE	Viral gene expression →	+0.086	+0.856	<.001	<.001	3	14
LIVER	Endoplasmic reticulum unfolded protein response →	+0.122	+0.942	.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,960 associations by consensus.

Cotranslational protein targeting to membrane by SIL1 expression — BONE

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