SIL1

Across TCGA cell cohorts, SIL1 protein abundance is significantly associated with the go_rna of many other GO terms, with 2,216 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SIL1-associated GO terms across cancer lineages are Regulation of G1/S transition of mitotic cell cycle, L-threonine metabolic process, and L-threonine catabolic process. Each is linked with SIL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SIL1-to-partner and partner-to-SIL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of G1/S transition of mitotic cell cycle grouped by SIL1-low versus SIL1-high in BLOOD_Lymphoma.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIL1→partner) and Y-score (partner→SIL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of G1/S transition of mitotic cell cycle →	-0.041	-0.969	.002	.002	3	4
BREAST	L-threonine metabolic process →	+0.249	+1.009	<.001	<.001	3	3
BREAST	L-threonine catabolic process →	+0.249	+1.009	<.001	<.001	3	3
CNS	Negative regulation of phagocytosis →	+0.084	+0.791	.004	.002	3	3
BREAST	Methionine transport →	-0.130	-0.901	<.001	<.001	3	3
BREAST	Cytokine production →	-0.171	-1.179	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,216 associations by consensus.

Regulation of G1/S transition of mitotic cell cycle by SIL1 expression — BLOOD_Lymphoma

Explore this box plot interactively →