SIL1

Across TCGA cell cohorts, SIL1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIL1-associated genes across cancer lineages are MYOD1, G6PC2, and DEFA4. Each is linked with SIL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIL1-to-partner and partner-to-SIL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYOD1 grouped by SIL1-low versus SIL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIL1→partner) and Y-score (partner→SIL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYOD1 →	+0.015	+4.922	.001	.009	3	2
LARGE_INTESTINE	G6PC2 →	+0.038	+3.099	<.001	.004	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
SKIN	PGK2 →	+0.046	+5.415	<.001	.004	3	1
BLOOD_Leukemia	LGI1 →	+0.129	+5.539	<.001	.003	3	1
BLOOD_Leukemia	MYF5 →	+0.013	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MYOD1 by SIL1 expression — BLOOD_Leukemia

Explore this box plot interactively →