SIKE1

Across TCGA patient cohorts, SIKE1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,439 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SIKE1-associated proteins across cancer lineages are TRIM33, MSH2, and PPP1R10. Each is linked with SIKE1 in more than 7 cancer types. Because this analysis shows association rather than direction, both SIKE1-to-partner and partner-to-SIKE1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIKE1 versus TRIM33 in HNSC, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SIKE1→partner) and Y-score (partner→SIKE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRIM33 →	+0.289	+0.766	<.001	<.001	3	8
GBM	MSH2 →	+0.428	+0.360	<.001	.003	3	5
GBM	PPP1R10 →	+0.302	+0.330	<.001	.005	3	5
GBM	RBM15 →	+0.217	+0.409	<.001	<.001	3	5
LSCC	SF3B1 →	+0.180	+0.422	<.001	.001	3	5
GBM	SMARCA4 →	+0.343	+0.403	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,439 associations by consensus.

SIKE1 vs TRIM33 — HNSC

Explore this scatter interactively →