SIKE1

Across TCGA patient cohorts, SIKE1 protein abundance is significantly associated with the RNA expression of many other genes, with 7,445 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIKE1-associated genes across cancer lineages are SYP, PTAFR, and MCCC1. Each is linked with SIKE1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SIKE1-to-partner and partner-to-SIKE1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIKE1 versus SYP in GBM, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIKE1→partner) and Y-score (partner→SIKE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SYP →	-1.411	-0.180	<.001	.002	3	4
UCEC	PTAFR →	+1.009	+0.173	<.001	.002	3	4
HNSC	MCCC1 →	-0.755	-0.204	<.001	.001	3	4
HNSC	UBR3 →	-0.684	-0.215	.004	.004	3	4
LSCC	MCCC1-AS1 →	-0.745	-0.184	<.001	<.001	3	4
GBM	OPHN1 →	-0.985	-0.216	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,445 associations by consensus.

SIKE1 vs SYP — GBM

Explore this scatter interactively →