SIKE1

Across TCGA cell cohorts, SIKE1 mutation is significantly associated with the mutation status of many other genes, with 245 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIKE1-associated genes across cancer lineages are IDH3B, MANSC1, and GPS2. Each is linked with SIKE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIKE1-to-partner and partner-to-SIKE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IDH3B grouped by SIKE1-low versus SIKE1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIKE1→partner) and Y-score (partner→SIKE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IDH3B →	+5.523	+5.523	.003	.003	1	2
LARGE_INTESTINE	MANSC1 →	+4.523	+5.087	.006	.006	1	2
SKIN	GPS2 →	+5.392	+4.824	.004	.004	1	2
LARGE_INTESTINE	WBP1L →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	SNTB2 →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	TEX44 →	+5.523	+5.523	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 245 associations by consensus.

IDH3B by SIKE1 expression — LARGE_INTESTINE

Explore this box plot interactively →