SIK3

Across TCGA pan-cancer cohorts, SIK3 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SIK3’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SIK3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SIK3 is over-expressed in tumor, although a few such as CCRCC and LUAD show the opposite, repressed pattern.

CCRCC, LUAD, and LSCC are the cancer types where SIK3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SIK3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	−0.306	<.001	9	view →
LUAD	Female	II,III,IV	−0.250	<.001	8	view →
LSCC	Male	II,III,IV	−0.189	<.001	7	view →
PDAC	All	All	−0.235	.010	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SIK3–CCRCC

Open the CCRCC breakdown →