SIK2

Across TCGA cell cohorts, SIK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,335 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIK2-associated GO terms across cancer lineages are Protein polyubiquitination, Positive regulation of TORC2 signaling, and Endosomal transport. Each is linked with SIK2 in more than 14 cancer types. Because this analysis shows association rather than direction, both SIK2-to-partner and partner-to-SIK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein polyubiquitination grouped by SIK2-low versus SIK2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIK2→partner) and Y-score (partner→SIK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Protein polyubiquitination →	+0.049	+0.718	<.001	<.001	3	15
STOMACH	Positive regulation of TORC2 signaling →	+0.147	+0.854	.006	.002	3	14
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.055	+0.670	<.001	<.001	3	12
KIDNEY	Cytosolic transport →	+0.074	+0.706	<.001	.003	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of DNA-templated transcription initiation →	+0.126	+0.927	<.001	<.001	3	12
CNS	Meiotic sister chromatid cohesion, centromeric →	+0.138	+0.840	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,335 associations by consensus.

Protein polyubiquitination by SIK2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →