SIK2

Across TCGA cell cohorts, SIK2 mutation is significantly associated with the RNA expression of many other genes, with 582 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIK2-associated genes across cancer lineages are PPIAL4F, CABP5, and CSTL1. Each is linked with SIK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIK2-to-partner and partner-to-SIK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAL4F grouped by SIK2-low versus SIK2-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIK2→partner) and Y-score (partner→SIK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PPIAL4F →	+0.133	+4.121	<.001	.006	3	1
BLOOD_Lymphoma	CABP5 →	+0.016	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	CSTL1 →	+0.573	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR8B12 →	+0.139	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	OR5P2 →	+0.018	+4.867	.001	.009	3	1
BLOOD_Lymphoma	OR8D1 →	+0.045	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 582 associations by consensus.

PPIAL4F by SIK2 expression — KIDNEY

Explore this box plot interactively →