SIGMAR1

Across TCGA pan-cancer cohorts, SIGMAR1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SIGMAR1 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SIGMAR1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SIGMAR1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, GBM, and CCRCC are the cancer types where SIGMAR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.784	0.512	.002	31	view →
GBM	DFS	Quartile	All	0.480	0.194	.018	4	view →
CCRCC	OS	Quartile	All	1.000	0.712	.010	4	view →
LUAD	DFS	Quartile	All	0.450	0.874	.041	4	view →
PDAC	OS	Tertile	All	0.765	0.435	.038	2	view →
LSCC	OS	Median	II,III,IV	0.903	0.750	.035	2	view →
UCEC	DFS	Median	All	0.944	1.000	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SIGMAR1–HNSC (DFS)

Open the HNSC breakdown →