SIGMAR1

Across TCGA patient cohorts, SIGMAR1 protein abundance is significantly associated with the RNA expression of many other genes, with 3,429 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SIGMAR1-associated genes across cancer lineages are DDA1, ARID3C, and LINC02319. Each is linked with SIGMAR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGMAR1-to-partner and partner-to-SIGMAR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIGMAR1 versus DDA1 in OV, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGMAR1→partner) and Y-score (partner→SIGMAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DDA1 →	+0.738	+0.548	<.001	.006	3	2
OV	ARID3C →	+0.911	+0.671	.002	.001	3	2
CCRCC	LINC02319 →	+0.241	+0.316	.003	.004	3	2
OV	CDIP1 →	+1.060	+0.775	.009	<.001	3	2
COAD	CD1B →	-0.422	-0.424	.003	.005	3	2
COAD	SPNS3 →	-0.536	-0.519	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,429 associations by consensus.

SIGMAR1 vs DDA1 — OV

Explore this scatter interactively →