SIGMAR1

Across TCGA cell cohorts, SIGMAR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,232 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SIGMAR1-associated GO terms across cancer lineages are tRNA export from nucleus, Response to methamphetamine hydrochloride, and G protein-coupled opioid receptor signaling pathway. Each is linked with SIGMAR1 in more than 14 cancer types. Because this analysis shows association rather than direction, both SIGMAR1-to-partner and partner-to-SIGMAR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA export from nucleus grouped by SIGMAR1-low versus SIGMAR1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGMAR1→partner) and Y-score (partner→SIGMAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	tRNA export from nucleus →	+0.145	+0.794	<.001	<.001	3	15
BLOOD_Lymphoma	Response to methamphetamine hydrochloride →	+0.279	+1.260	.005	<.001	3	14
BREAST	G protein-coupled opioid receptor signaling pathway →	+0.537	+1.148	.003	.001	3	14
URINARY_TRACT	GMP biosynthetic process →	+0.134	+0.997	<.001	<.001	3	11
LUNG_SCLC	Purine ribonucleoside monophosphate biosynthetic process →	+0.111	+0.657	<.001	<.001	3	10
BONE	RNA localization to Cajal body →	+0.125	+0.841	.009	.002	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,232 associations by consensus.

tRNA export from nucleus by SIGMAR1 expression — OESOPHAGUS

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