SIGLECL1

Across TCGA patient cohorts, SIGLECL1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIGLECL1-associated genes across cancer lineages are Cyclin-E2, GAPDH, and GATA6. Each is linked with SIGLECL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLECL1-to-partner and partner-to-SIGLECL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by SIGLECL1-low versus SIGLECL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLECL1→partner) and Y-score (partner→SIGLECL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.218	+2.817	.013	.036	3	2
UCEC	GAPDH →	+0.790	+3.321	.004	.010	3	1
UCEC	GATA6 →	-0.207	-3.314	.010	.010	3	1
UCEC	Ku80 →	+0.367	+3.335	.003	.005	3	1
UCEC	Tuberin →	+0.467	+2.817	<.001	.036	3	1
UCEC	Caspase-8 →	-0.328	-3.321	.012	.010	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Cyclin-E2 by SIGLECL1 expression — UCEC

Explore this box plot interactively →