SIGLECL1

Across TCGA cell cohorts, SIGLECL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 486 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SIGLECL1-associated GO terms across cancer lineages are Glutathione biosynthetic process, Negative regulation of receptor recycling, and Regulation of ferroptosis. Each is linked with SIGLECL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIGLECL1-to-partner and partner-to-SIGLECL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glutathione biosynthetic process grouped by SIGLECL1-low versus SIGLECL1-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLECL1→partner) and Y-score (partner→SIGLECL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Glutathione biosynthetic process →	+0.078	+0.917	.004	.008	3	3
BLOOD_Lymphoma	Negative regulation of receptor recycling →	+0.115	+0.967	<.001	.007	3	2
BLOOD_Lymphoma	Regulation of ferroptosis →	+0.114	+0.986	<.001	.006	3	2
BLOOD_Lymphoma	Positive regulation of cGAS/STING signaling pathway →	-0.071	-0.734	<.001	.004	3	2
BLOOD_Lymphoma	Protein import →	+0.200	+0.996	<.001	.005	3	2
BLOOD_Lymphoma	Leukotriene D4 biosynthetic process →	+0.769	+0.940	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 486 associations by consensus.

Glutathione biosynthetic process by SIGLECL1 expression — BLOOD_Lymphoma

Explore this box plot interactively →