SIGLEC9

Across TCGA patient cohorts, SIGLEC9 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIGLEC9-associated genes across cancer lineages are ASNS, eEF2, and GATA6. Each is linked with SIGLEC9 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIGLEC9-to-partner and partner-to-SIGLEC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SIGLEC9-low versus SIGLEC9-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC9→partner) and Y-score (partner→SIGLEC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.861	+2.815	<.001	.036	3	3
UCEC	eEF2 →	+0.533	+3.169	<.001	.018	3	2
UCEC	GATA6 →	-0.150	-2.314	.019	.006	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.449	-3.584	.015	.002	3	2
UCEC	PDCD4 →	-0.744	-3.000	<.001	.001	3	2
UCEC	Stathmin →	+0.116	+1.807	.040	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

ASNS by SIGLEC9 expression — COAD

Explore this box plot interactively →