SIGLEC9

Across TCGA cell cohorts, SIGLEC9 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,296 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIGLEC9-associated GO terms across cancer lineages are Fat cell proliferation, Regulation of focal adhesion assembly, and Regulation of cell-substrate junction assembly. Each is linked with SIGLEC9 in more than 5 cancer types. Because this analysis shows association rather than direction, both SIGLEC9-to-partner and partner-to-SIGLEC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fat cell proliferation grouped by SIGLEC9-low versus SIGLEC9-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC9→partner) and Y-score (partner→SIGLEC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Fat cell proliferation →	+0.209	+0.061	.006	.004	3	6
BLOOD_Leukemia	Regulation of focal adhesion assembly →	+0.056	+0.557	<.001	.002	3	6
BLOOD_Leukemia	Regulation of cell-substrate junction assembly →	+0.056	+0.557	<.001	.002	3	6
SOFT_TISSUE	Regulation of protein localization to mitochondrion →	+0.101	+0.160	<.001	.004	3	5
LUNG_NSCLC_LUAD	Mitochondrial fragmentation involved in apoptotic process →	+0.146	+0.072	<.001	.009	3	5
LUNG_NSCLC_LUSC	Regulation of protein localization to membrane →	+0.073	+0.055	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,296 associations by consensus.

Fat cell proliferation by SIGLEC9 expression — OVARY

Explore this box plot interactively →