SIGLEC9

Across TCGA cell cohorts, SIGLEC9 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIGLEC9-associated genes across cancer lineages are FCN2, MAGEB10, and BTNL2. Each is linked with SIGLEC9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLEC9-to-partner and partner-to-SIGLEC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN2 grouped by SIGLEC9-low versus SIGLEC9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC9→partner) and Y-score (partner→SIGLEC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FCN2 →	+0.039	+4.415	<.001	.007	3	1
LARGE_INTESTINE	MAGEB10 →	+0.109	+4.930	<.001	.001	3	1
LARGE_INTESTINE	BTNL2 →	+0.081	+4.415	<.001	.007	3	1
LARGE_INTESTINE	KRTAP10-1 →	+0.009	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR5V1 →	+0.010	+5.022	<.001	.002	3	1
LARGE_INTESTINE	CD300H →	+0.055	+6.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FCN2 by SIGLEC9 expression — LARGE_INTESTINE

Explore this box plot interactively →