SIGLEC7

Across TCGA patient cohorts, SIGLEC7 protein abundance is significantly associated with the RNA expression of many other genes, with 13,361 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIGLEC7-associated genes across cancer lineages are WAS, CD53, and LRRC25. Each is linked with SIGLEC7 in more than 6 cancer types. Because this analysis shows association rather than direction, both SIGLEC7-to-partner and partner-to-SIGLEC7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIGLEC7 versus WAS in HNSC, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC7→partner) and Y-score (partner→SIGLEC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	WAS →	+1.333	+0.819	<.001	<.001	3	7
HNSC	CD53 →	+1.848	+0.965	<.001	<.001	3	6
HNSC	LRRC25 →	+1.083	+0.690	.005	.002	3	6
HNSC	SIGLEC14 →	+1.232	+0.606	<.001	<.001	3	6
GBM	CCL4 →	+1.541	+0.544	<.001	<.001	3	6
HNSC	SPI1 →	+1.306	+0.701	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,361 associations by consensus.

SIGLEC7 vs WAS — HNSC

Explore this scatter interactively →