SIGLEC7

Across TCGA patient cohorts, SIGLEC7 mutation is significantly associated with the RNA expression of many other genes, with 3,591 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIGLEC7-associated genes across cancer lineages are HDGFL2, POM121C, and DOC2B. Each is linked with SIGLEC7 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIGLEC7-to-partner and partner-to-SIGLEC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HDGFL2 grouped by SIGLEC7-low versus SIGLEC7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC7→partner) and Y-score (partner→SIGLEC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HDGFL2 →	+0.487	+2.070	<.001	.001	3	3
UCEC	POM121C →	+0.493	+3.742	<.001	<.001	3	2
UCEC	DOC2B →	-0.987	-1.736	<.001	.007	3	2
UCEC	ZNHIT3 →	+0.407	+2.091	.001	.001	3	2
UCEC	AATF →	+0.408	+3.584	.001	<.001	3	2
UCEC	UHRF1 →	+1.046	+2.949	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,591 associations by consensus.

HDGFL2 by SIGLEC7 expression — UCEC

Explore this box plot interactively →