SIGLEC7

Across TCGA cell cohorts, SIGLEC7 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,713 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIGLEC7-associated GO terms across cancer lineages are Negative regulation of hyaluronan biosynthetic process, Regulation of ERBB signaling pathway, and Myelination in peripheral nervous system. Each is linked with SIGLEC7 in more than 4 cancer types. Because this analysis shows association rather than direction, both SIGLEC7-to-partner and partner-to-SIGLEC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of hyaluronan biosynthetic process grouped by SIGLEC7-low versus SIGLEC7-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC7→partner) and Y-score (partner→SIGLEC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Negative regulation of hyaluronan biosynthetic process →	+0.089	+1.084	<.001	<.001	3	5
BLOOD_Leukemia	Regulation of ERBB signaling pathway →	+0.036	+1.337	.001	.001	3	4
BLOOD_Leukemia	Myelination in peripheral nervous system →	+0.060	+0.875	<.001	.001	3	4
BLOOD_Leukemia	Peripheral nervous system axon ensheathment →	+0.060	+0.875	<.001	.001	3	4
BLOOD_Leukemia	Response to vitamin E →	+0.085	+1.130	<.001	<.001	3	4
BLOOD_Leukemia	Establishment of protein localization to extracellular region →	+0.056	+1.307	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,713 associations by consensus.

Negative regulation of hyaluronan biosynthetic process by SIGLEC7 expression — BLOOD_Leukemia

Explore this box plot interactively →