SIGLEC7

Across TCGA cell cohorts, SIGLEC7 mutation is significantly associated with the RNA expression of many other genes, with 328 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIGLEC7-associated genes across cancer lineages are LUZP4, RERGL, and TNP1. Each is linked with SIGLEC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLEC7-to-partner and partner-to-SIGLEC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LUZP4 grouped by SIGLEC7-low versus SIGLEC7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC7→partner) and Y-score (partner→SIGLEC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LUZP4 →	+0.322	+3.475	<.001	.006	3	1
BLOOD_Leukemia	RERGL →	+1.087	+3.551	<.001	.008	3	1
BLOOD_Leukemia	TNP1 →	+0.111	+4.569	<.001	.003	3	1
BLOOD_Leukemia	KAAG1 →	+0.085	+4.177	<.001	.001	3	1
BLOOD_Leukemia	C8A →	+0.014	+3.684	<.001	.004	3	1
BLOOD_Leukemia	SPATA19 →	+0.015	+4.569	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 328 associations by consensus.

LUZP4 by SIGLEC7 expression — BLOOD_Leukemia

Explore this box plot interactively →