SIGLEC6

Across TCGA patient cohorts, SIGLEC6 protein abundance is significantly associated with the RNA expression of many other genes, with 3,598 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SIGLEC6-associated genes across cancer lineages are SRPRB, CTSG, and SLC8A3. Each is linked with SIGLEC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLEC6-to-partner and partner-to-SIGLEC6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIGLEC6 versus SRPRB in LSCC, with a Pearson correlation of -0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC6→partner) and Y-score (partner→SIGLEC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SRPRB →	-0.645	-0.524	.001	.006	3	2
LUAD	CTSG →	+1.443	+0.428	.003	.009	3	1
LUAD	SLC8A3 →	+0.584	+0.425	<.001	<.001	3	1
LUAD	PRORP →	-0.593	-0.447	.001	<.001	3	1
LUAD	VSIG1 →	+2.437	+0.369	.004	.003	3	1
LUAD	TBL1X →	-0.733	-0.349	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,598 associations by consensus.

SIGLEC6 vs SRPRB — LSCC

Explore this scatter interactively →