SIGLEC6

Across TCGA cell cohorts, SIGLEC6 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,931 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIGLEC6-associated GO terms across cancer lineages are Cellular response to morphine, Cellular response to isoquinoline alkaloid, and Apoptotic cell clearance. Each is linked with SIGLEC6 in more than 4 cancer types. Because this analysis shows association rather than direction, both SIGLEC6-to-partner and partner-to-SIGLEC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to morphine grouped by SIGLEC6-low versus SIGLEC6-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC6→partner) and Y-score (partner→SIGLEC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Cellular response to morphine →	+0.092	+0.146	<.001	.005	3	5
BLOOD_Lymphoma	Cellular response to isoquinoline alkaloid →	+0.092	+0.146	<.001	.005	3	5
LARGE_INTESTINE	Apoptotic cell clearance →	+0.135	+1.567	<.001	.004	3	4
SOFT_TISSUE	Regulation of intracellular protein transport →	+0.057	+0.017	<.001	.005	3	4
BLOOD_Leukemia	Sterol transport →	+0.046	+1.924	<.001	<.001	3	4
BLOOD_Leukemia	Negative regulation of endoplasmic reticulum unfolded protein response →	+0.072	+1.868	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,931 associations by consensus.

Cellular response to morphine by SIGLEC6 expression — BLOOD_Lymphoma

Explore this box plot interactively →