SIGLEC6

Across TCGA cell cohorts, SIGLEC6 mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIGLEC6-associated genes across cancer lineages are CELA1, CFC1B, and PRAMEF10. Each is linked with SIGLEC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLEC6-to-partner and partner-to-SIGLEC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CELA1 grouped by SIGLEC6-low versus SIGLEC6-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC6→partner) and Y-score (partner→SIGLEC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CELA1 →	+0.028	+4.058	<.001	.007	3	1
LUNG_SCLC	CFC1B →	+0.178	+3.736	<.001	.007	3	1
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF17 →	+0.008	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF14 →	+0.232	+3.523	<.001	.008	3	1
LUNG_SCLC	C3orf56 →	+0.009	+4.169	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

CELA1 by SIGLEC6 expression — LUNG_SCLC

Explore this box plot interactively →