SIGLEC5

Across TCGA patient cohorts, SIGLEC5 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIGLEC5-associated genes across cancer lineages are ERK2, TFRC, and eIF4E. Each is linked with SIGLEC5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIGLEC5-to-partner and partner-to-SIGLEC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SIGLEC5-low versus SIGLEC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC5→partner) and Y-score (partner→SIGLEC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.237	+2.700	.001	.005	3	3
UCEC	TFRC →	+0.437	+2.999	.032	.035	3	3
LUSC	eIF4E →	+0.145	+2.331	.034	.019	3	2
SKCM	Stathmin →	+0.148	+3.087	.016	<.001	3	2
UCEC	Cyclin-B1 →	+0.561	+2.087	.009	.005	3	2
UCEC	eEF2 →	+0.367	+2.321	.007	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ERK2 by SIGLEC5 expression — UCEC

Explore this box plot interactively →