SIGLEC5

Across TCGA cell cohorts, SIGLEC5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,185 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIGLEC5-associated GO terms across cancer lineages are Positive regulation of bone development, Response to lipoteichoic acid, and Cellular response to lipoteichoic acid. Each is linked with SIGLEC5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIGLEC5-to-partner and partner-to-SIGLEC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of bone development grouped by SIGLEC5-low versus SIGLEC5-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC5→partner) and Y-score (partner→SIGLEC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Positive regulation of bone development →	-0.302	-1.004	<.001	<.001	3	3
BLOOD_Leukemia	Response to lipoteichoic acid →	-0.116	-0.845	.001	.002	3	3
BLOOD_Leukemia	Cellular response to lipoteichoic acid →	-0.116	-0.845	.001	.002	3	3
BLOOD_Leukemia	Regulation of inositol phosphate biosynthetic process →	+1.026	+0.835	<.001	<.001	3	2
BLOOD_Leukemia	Negative regulation of cell-substrate junction organization →	+0.096	+1.006	<.001	<.001	3	2
BLOOD_Leukemia	rRNA catabolic process →	+0.033	+0.895	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,185 associations by consensus.

Positive regulation of bone development by SIGLEC5 expression — BLOOD_Leukemia

Explore this box plot interactively →