SIGLEC29P

Across TCGA pan-cancer cohorts, SIGLEC29P RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated SIGLEC29P data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher SIGLEC29P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SIGLEC29P expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

UVM, KIRC, and THCA are the cancer types where SIGLEC29P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	II,III,IV	0.218	0.718	.006	72	view →
KIRC	DFS	Tertile	II,III,IV	0.401	0.564	.015	24	view →
THCA	OS	Tertile	II,III,IV	0.863	0.972	.002	24	view →
ESCA	DFS	Tertile	II,III,IV	0.134	0.844	.013	18	view →
LUSC	OS	Tertile	II,III,IV	0.275	0.618	.026	18	view →
LUAD	OS	Tertile	II,III,IV	0.151	0.682	<.001	18	view →
LIHC	OS	Tertile	III,IV	0.271	0.658	.020	9	view →
LGG	OS	Tertile	All	0.763	0.896	.043	3	view →
HNSC	DFS	Tertile	II,III,IV	0.590	0.266	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

SIGLEC29P–UVM (OS)

Open the UVM breakdown →