SIGLEC27P

Across TCGA pan-cancer cohorts, SIGLEC27P RNA is linked to patient survival in 3 of 34 cancer types, making it the most broadly survival-associated SIGLEC27P data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SIGLEC27P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SIGLEC27P expression acts as an unfavorable survival marker.

BLCA, LIHC, and THCA are the cancer types where SIGLEC27P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	III,IV	0.145	0.552	<.001	81	view →
LIHC	DFS	Tertile	II,III,IV	0.080	0.427	.019	18	view →
THCA	OS	Tertile	All	0.323	0.955	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SIGLEC27P–BLCA (DFS)

Open the BLCA breakdown →