SIGLEC22P

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SIGLEC22P RNA expression is significantly associated with the protein abundance of many other proteins, with 16,848 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIGLEC22P-associated proteins across cancer lineages are DOCK8, ANKRD44, and BTK. Each is linked with SIGLEC22P in more than 8 cancer types. Because this analysis shows association rather than direction, both SIGLEC22P-to-partner and partner-to-SIGLEC22P results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIGLEC22P versus DOCK8 in GBM, with a Pearson correlation of 0.80.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC22P→partner) and Y-score (partner→SIGLEC22P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMDOCK8 →+0.571+0.769<.001<.00139
OVANKRD44 →+0.376+0.392<.001<.00139
GBMBTK →+0.556+0.730<.001<.00139
GBMAIF1 →+0.875+0.799<.001<.00139
GBMAPBB1IP →+0.641+0.733<.001<.00139
GBMNCKAP1L →+0.680+0.784<.001<.00138
Each partner links to its Q-omics profile. Showing the 6 strongest of 16,848 associations by consensus.

SIGLEC22P vs DOCK8 — GBM

Per-sample scatter of SIGLEC22P vs DOCK8 in GBM (Pearson r = 0.80).

Explore this scatter interactively →

Exploration