SIGLEC16

Across TCGA patient cohorts, SIGLEC16 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,117 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible SIGLEC16-associated GO terms across cancer lineages are Interferon-mediated signaling pathway, Positive regulation of tumor necrosis factor superfamily cytokine production, and Regulation of myeloid cell differentiation. Each is linked with SIGLEC16 in more than 27 cancer types. Because this analysis shows association rather than direction, both SIGLEC16-to-partner and partner-to-SIGLEC16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Interferon-mediated signaling pathway grouped by SIGLEC16-low versus SIGLEC16-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC16→partner) and Y-score (partner→SIGLEC16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Interferon-mediated signaling pathway →	+0.040	+0.353	<.001	<.001	3	28
LAML	Positive regulation of tumor necrosis factor superfamily cytokine production →	+0.095	+1.754	<.001	<.001	3	27
ESCA	Regulation of myeloid cell differentiation →	+0.038	+0.328	<.001	<.001	3	27
LGG	Antigen processing and presentation of exogenous peptide antigen via MHC class II →	+0.103	+0.496	<.001	<.001	3	27
LAML	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell →	+0.163	+1.468	<.001	<.001	3	27
LAML	Regulation of T-helper 17 type immune response →	+0.050	+1.279	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,117 associations by consensus.

Interferon-mediated signaling pathway by SIGLEC16 expression — ESCA

Explore this box plot interactively →