SIGLEC16

Across TCGA patient cohorts, SIGLEC16 mutation is significantly associated with the RNA expression of many other genes, with 239 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIGLEC16-associated genes across cancer lineages are RN7SL679P, RPL34P3, and SOCS5P3. Each is linked with SIGLEC16 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLEC16-to-partner and partner-to-SIGLEC16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL679P grouped by SIGLEC16-low versus SIGLEC16-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC16→partner) and Y-score (partner→SIGLEC16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL679P →	+0.089	+2.931	.001	.006	3	2
LUSC	RPL34P3 →	+0.172	+4.984	.005	.009	3	2
SKCM	SOCS5P3 →	+0.049	+2.725	<.001	.006	3	1
SKCM	HS6ST2-AS1 →	+0.074	+3.224	<.001	.007	3	1
SKCM	LINC01448 →	+0.451	+2.638	.002	.007	3	1
SKCM	RN7SL346P →	+0.043	+4.411	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 239 associations by consensus.

RN7SL679P by SIGLEC16 expression — SKCM

Explore this box plot interactively →