SIGLEC16

Across TCGA patient cohorts, SIGLEC16 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIGLEC16-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and Notch1. Each is linked with SIGLEC16 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLEC16-to-partner and partner-to-SIGLEC16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SIGLEC16-low versus SIGLEC16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC16→partner) and Y-score (partner→SIGLEC16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.269	-3.459	.032	.005	3	1
UCEC	FoxM1 →	+0.268	+2.321	.039	.035	3	1
UCEC	Notch1 →	+0.244	+3.013	<.001	.018	3	1
UCEC	PCNA →	+0.230	+3.459	.034	.005	3	1
UCEC	Annexin-1 →	+0.792	+2.827	.002	.035	3	1
UCEC	Tuberin →	+0.284	+2.179	.036	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

EGFR_pY1068 by SIGLEC16 expression — UCEC

Explore this box plot interactively →