SIGLEC16

Across TCGA cell cohorts, SIGLEC16 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,122 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SIGLEC16-associated GO terms across cancer lineages are Cytosolic transport, Epigenetic regulation of gene expression, and Protein polyubiquitination. Each is linked with SIGLEC16 in more than 6 cancer types. Because this analysis shows association rather than direction, both SIGLEC16-to-partner and partner-to-SIGLEC16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytosolic transport grouped by SIGLEC16-low versus SIGLEC16-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC16→partner) and Y-score (partner→SIGLEC16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Cytosolic transport →	+0.042	+0.052	<.001	.002	3	7
SOFT_TISSUE	Epigenetic regulation of gene expression →	+0.046	+0.065	.002	.006	3	7
CNS	Protein polyubiquitination →	+0.020	+0.024	.005	.002	3	7
LUNG_SCLC	Glycerophospholipid biosynthetic process →	+0.030	+0.130	.006	.002	3	6
SKIN	Phosphatidylinositol phosphate biosynthetic process →	+0.042	+0.021	.001	.007	3	6
CNS	Negative regulation of autophagy →	+0.050	+0.042	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,122 associations by consensus.

Cytosolic transport by SIGLEC16 expression — SOFT_TISSUE

Explore this box plot interactively →