SIGLEC14

Across TCGA patient cohorts, SIGLEC14 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIGLEC14-associated genes across cancer lineages are IGFBP2, JNK_pT183_Y185, and Rab25. Each is linked with SIGLEC14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLEC14-to-partner and partner-to-SIGLEC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by SIGLEC14-low versus SIGLEC14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC14→partner) and Y-score (partner→SIGLEC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.858	-3.000	.008	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.184	-2.308	.030	.036	3	1
UCEC	Rab25 →	-0.450	-2.321	.006	.035	3	1
UCEC	Cyclin-B1 →	+0.845	+2.321	.002	.035	3	1
SKCM	PI3K-p85 →	+0.231	+3.584	.022	.002	3	1
LUSC	Rictor_pT1135 →	-0.197	-2.990	.002	.036	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

IGFBP2 by SIGLEC14 expression — UCEC

Explore this box plot interactively →