SIGLEC14

Across TCGA cell cohorts, SIGLEC14 RNA expression is significantly associated with the RNA expression of many other genes, with 4,541 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIGLEC14-associated genes across cancer lineages are SIGLEC5, CXCR2, and CSF2RB. Each is linked with SIGLEC14 in more than 6 cancer types. Because this analysis shows association rather than direction, both SIGLEC14-to-partner and partner-to-SIGLEC14 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIGLEC14 versus SIGLEC5 in BLOOD_Leukemia, with a Pearson correlation of 0.74.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC14→partner) and Y-score (partner→SIGLEC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SIGLEC5 →	+1.304	+1.761	<.001	<.001	3	7
BLOOD_Leukemia	CXCR2 →	+1.128	+1.177	<.001	<.001	3	4
BLOOD_Leukemia	CSF2RB →	+2.018	+1.034	<.001	<.001	3	3
SKIN	IZUMO1R →	+0.132	+0.056	.001	<.001	3	3
BLOOD_Lymphoma	CCL4 →	+1.730	+0.417	<.001	<.001	3	2
BLOOD_Lymphoma	CCL3 →	+3.128	+0.618	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,541 associations by consensus.

SIGLEC14 vs SIGLEC5 — BLOOD_Leukemia

Explore this scatter interactively →