SIGLEC14

Across TCGA cell cohorts, SIGLEC14 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,911 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIGLEC14-associated GO terms across cancer lineages are Mitotic G1/S transition checkpoint signaling, Hormone transport, and RNA methylation. Each is linked with SIGLEC14 in more than 4 cancer types. Because this analysis shows association rather than direction, both SIGLEC14-to-partner and partner-to-SIGLEC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic G1/S transition checkpoint signaling grouped by SIGLEC14-low versus SIGLEC14-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC14→partner) and Y-score (partner→SIGLEC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Mitotic G1/S transition checkpoint signaling →	+0.087	+0.029	<.001	.009	3	5
BLOOD_Leukemia	Hormone transport →	+0.073	+0.979	<.001	<.001	3	3
BLOOD_Lymphoma	RNA methylation →	+0.028	+0.428	.006	.006	3	3
BLOOD_Lymphoma	Blastocyst growth →	+0.079	+0.494	.005	.006	3	3
BLOOD_Leukemia	Toll-like receptor signaling pathway →	+0.038	+1.261	<.001	<.001	3	3
BLOOD_Lymphoma	Epithelial cell differentiation involved in kidney development →	+0.073	+0.486	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,911 associations by consensus.

Mitotic G1/S transition checkpoint signaling by SIGLEC14 expression — CNS

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