SIGLEC14

Across TCGA cell cohorts, SIGLEC14 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SIGLEC14-associated genes across cancer lineages are H2BC1, H2AC1, and OR8B12. Each is linked with SIGLEC14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLEC14-to-partner and partner-to-SIGLEC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC1 grouped by SIGLEC14-low versus SIGLEC14-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC14→partner) and Y-score (partner→SIGLEC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	H2BC1 →	+0.433	+5.977	<.001	.001	3	1
SOFT_TISSUE	H2AC1 →	+0.193	+5.977	<.001	.001	3	1
SOFT_TISSUE	OR8B12 →	+0.041	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR8B8 →	+0.046	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR10D3 →	+0.081	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR2M2 →	+0.018	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

H2BC1 by SIGLEC14 expression — SOFT_TISSUE

Explore this box plot interactively →