SIGLEC12

Across TCGA patient cohorts, SIGLEC12 mutation is significantly associated with the RNA expression of many other genes, with 2,252 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIGLEC12-associated genes across cancer lineages are APOOP2, UBXN6, and RCE1. Each is linked with SIGLEC12 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIGLEC12-to-partner and partner-to-SIGLEC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOOP2 grouped by SIGLEC12-low versus SIGLEC12-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC12→partner) and Y-score (partner→SIGLEC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	APOOP2 →	+0.262	+4.090	<.001	.004	3	3
UCEC	UBXN6 →	+0.346	+2.828	.002	.001	3	3
SKCM	RCE1 →	+0.319	+2.038	<.001	.001	3	3
SKCM	CIDECP1 →	+0.365	+1.697	<.001	<.001	3	3
SKCM	ATAD3A →	+0.311	+1.350	.008	.006	3	3
SKCM	SULT1C4 →	-0.590	-2.440	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,252 associations by consensus.

APOOP2 by SIGLEC12 expression — STAD

Explore this box plot interactively →