SIGLEC12

Across TCGA patient cohorts, SIGLEC12 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIGLEC12-associated genes across cancer lineages are MYH11, MEK1, and mTOR_pS2448. Each is linked with SIGLEC12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLEC12-to-partner and partner-to-SIGLEC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH11 grouped by SIGLEC12-low versus SIGLEC12-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC12→partner) and Y-score (partner→SIGLEC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MYH11 →	-1.272	-1.874	.001	.049	3	2
UCEC	MEK1 →	+0.343	+2.115	.009	.017	3	2
UCEC	mTOR_pS2448 →	-0.125	-2.102	.019	.016	3	2
UCEC	Notch1 →	+0.173	+1.925	<.001	.005	3	2
UCEC	VHL →	-0.834	-1.925	<.001	.005	3	2
UCEC	ATM →	-0.515	-2.321	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MYH11 by SIGLEC12 expression — LUSC

Explore this box plot interactively →