SIGLEC12

Across TCGA cell cohorts, SIGLEC12 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,147 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIGLEC12-associated GO terms across cancer lineages are Neutrophil-mediated killing of fungus, Negative regulation of beige fat cell differentiation, and Positive regulation of respiratory gaseous exchange. Each is linked with SIGLEC12 in more than 3 cancer types. Because this analysis shows association rather than direction, both SIGLEC12-to-partner and partner-to-SIGLEC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neutrophil-mediated killing of fungus grouped by SIGLEC12-low versus SIGLEC12-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC12→partner) and Y-score (partner→SIGLEC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Neutrophil-mediated killing of fungus →	+0.961	+1.595	<.001	<.001	3	4
LIVER	Negative regulation of beige fat cell differentiation →	-0.158	-0.037	.001	.002	3	3
LIVER	Positive regulation of respiratory gaseous exchange →	+1.507	+0.028	<.001	.001	3	3
BLOOD_Leukemia	Interleukin-3-mediated signaling pathway →	+0.283	+2.037	.007	<.001	3	3
BREAST	Lipid droplet disassembly →	+0.129	+0.024	.005	.005	3	3
BLOOD_Leukemia	Regulation of glial cell migration →	-0.157	-2.111	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,147 associations by consensus.

Neutrophil-mediated killing of fungus by SIGLEC12 expression — BLOOD_Leukemia

Explore this box plot interactively →