SIGLEC12

Across TCGA cell cohorts, SIGLEC12 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIGLEC12-associated genes across cancer lineages are DCD, SH3GL2, and ACAA2. Each is linked with SIGLEC12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIGLEC12-to-partner and partner-to-SIGLEC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCD grouped by SIGLEC12-low versus SIGLEC12-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC12→partner) and Y-score (partner→SIGLEC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DCD →	+0.046	+4.643	<.001	.008	3	1
LARGE_INTESTINE	SH3GL2 →	+1.338	+3.667	<.001	<.001	3	1
LARGE_INTESTINE	ACAA2 →	+1.636	+3.067	<.001	.009	3	1
LARGE_INTESTINE	TAFA1 →	+0.187	+3.009	.006	.001	3	1
LARGE_INTESTINE	THNSL1 →	+0.911	+3.087	<.001	.006	3	1
LARGE_INTESTINE	MINAR2 →	+0.024	+2.560	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

DCD by SIGLEC12 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →