SIGLEC12

Across TCGA cell cohorts, SIGLEC12 mutation is significantly associated with the mutation status of many other genes, with 3,877 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIGLEC12-associated genes across cancer lineages are CACNA1F, ZC3H13, and WDFY4. Each is linked with SIGLEC12 in more than 4 cancer types. Because this analysis shows association rather than direction, both SIGLEC12-to-partner and partner-to-SIGLEC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CACNA1F grouped by SIGLEC12-low versus SIGLEC12-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC12→partner) and Y-score (partner→SIGLEC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CACNA1F →	+2.478	+2.662	.003	.003	1	5
BLOOD_Lymphoma	ZC3H13 →	+3.025	+3.754	.006	.006	1	4
BLOOD_Lymphoma	WDFY4 →	+3.078	+4.742	<.001	<.001	1	4
BLOOD_Lymphoma	TRANK1 →	+2.832	+3.601	.008	.008	1	4
SOFT_TISSUE	ADAMTSL1 →	+5.502	+5.502	.003	.003	1	4
BLOOD_Lymphoma	FAM83H →	+3.510	+4.108	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,877 associations by consensus.

CACNA1F by SIGLEC12 expression — SKIN

Explore this box plot interactively →