SIGLEC11

Across TCGA patient cohorts, SIGLEC11 mutation is significantly associated with the RNA expression of many other genes, with 1,391 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIGLEC11-associated genes across cancer lineages are UFD1, MIR676, and TCEA1P4. Each is linked with SIGLEC11 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIGLEC11-to-partner and partner-to-SIGLEC11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UFD1 grouped by SIGLEC11-low versus SIGLEC11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC11→partner) and Y-score (partner→SIGLEC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UFD1 →	+0.316	+2.616	.003	.005	3	3
OV	MIR676 →	+0.367	+4.991	<.001	.009	3	3
SKCM	TCEA1P4 →	+0.182	+2.141	.006	.009	3	2
SKCM	RPS3AP29 →	+0.060	+1.984	<.001	<.001	3	2
SKCM	RN7SL738P →	+0.252	+2.757	.007	.002	3	2
COAD	LINC02084 →	+0.549	+3.276	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,391 associations by consensus.

UFD1 by SIGLEC11 expression — UCEC

Explore this box plot interactively →