SIGLEC11

Across TCGA cell cohorts, SIGLEC11 RNA expression is significantly associated with the go_rna of many other GO terms, with 607 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SIGLEC11-associated GO terms across cancer lineages are Cellular response to thyroid hormone stimulus, Regulation of synaptic transmission, glutamatergic, and Regulation of cytoplasmic mRNA processing body assembly. Each is linked with SIGLEC11 in more than 4 cancer types. Because this analysis shows association rather than direction, both SIGLEC11-to-partner and partner-to-SIGLEC11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to thyroid hormone stimulus grouped by SIGLEC11-low versus SIGLEC11-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC11→partner) and Y-score (partner→SIGLEC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Cellular response to thyroid hormone stimulus →	+0.114	+0.035	<.001	.006	3	4
BLOOD_Lymphoma	Regulation of synaptic transmission, glutamatergic →	-0.055	-0.039	.004	.008	2	5
SOFT_TISSUE	Regulation of cytoplasmic mRNA processing body assembly →	+0.084	+0.399	<.001	.005	3	4
SOFT_TISSUE	Negative regulation of adenylate cyclase activity →	-0.148	-0.691	.002	.009	3	4
BLOOD_Leukemia	N-terminal protein amino acid acetylation →	+0.132	+0.270	<.001	.005	3	3
SOFT_TISSUE	Regulation of systemic arterial blood pressure mediated by a chemical signal →	-0.175	-0.393	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 607 associations by consensus.

Cellular response to thyroid hormone stimulus by SIGLEC11 expression — BREAST

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