SIGLEC10

mass-spec protein — tumor vs normal
Tumor vs Normalmass-specBox plot · TCGA cohorts

Across TCGA pan-cancer cohorts, SIGLEC10 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SIGLEC10’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where SIGLEC10 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SIGLEC10 is over-expressed in tumor.

LSCC and PDAC are the cancer types where SIGLEC10 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SIGLEC10 mass-spec protein (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.
LineageGenderStageFold-changepSampling consensus
LSCCAllAll+0.215.0014view →
PDACFemaleAll+0.576.0272view →
Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

SIGLEC10–LSCC

Tumor-vs-normal mass-spec protein box plot for SIGLEC10 in LSCC.

Open the LSCC breakdown →

Exploration